Proteometer-CV Kit
Proteometer-CV: Rapid, Reliable Charge Variant Analysis
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The Proteometer-CV is designed for scientists developing mAbs, bi-specifics, or fusion proteins with an Fc region, regardless of their position in the development process.
Unlike current charge variant (CV) methods, the Proteometer-CV does not require additional sample preparation or purification because testing is done directly in crude fermentation supernatant. Therefore, the development of a specialized method and the use of a specialized instrument are not required.
The Proteometer-CV provides customers with charge variant analysis in 25 minutes.
The kit reduces the need for capillary electrophoretic methods that require Protein A purification, thus saving time and money. We are the only solution that performs charge variant analysis in cell free supernatant, ensuring no negative effects on the sample that might be present in other charge variant methods.
Features and Benefits​​​​​​​​​​​​​​​​
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No Sample Preparation Required
Say goodbye to time-consuming purification steps. Unlike traditional methods, the Proteometer-CV allows you to perform CV analysis directly from clarified fermentation broth without requiring Protein A purification.
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Speed and Efficiency
Complete your CV analysis in under 25 minutes. The Proteometer-CV delivers fast, reproducible, and accurate results, reducing the time and cost associated with capillary electrophoresis methods.
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Simplified Workflow
Our kit has all the components you need for a seamless operation: specialized reactor, derivatizer module (MD2), buffer packets, fluorescent reagent, tubing unions, and easy-to-follow instructions. Mix mobile phases, inject samples, and get your results—it's that simple.
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Exclusive Technology
The Proteometer-CV is the only solution that performs charge variant analysis directly in broth, ensuring that the fermentation medium does not interfere with your results.
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Components
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Specialized Reactor
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Derivatizer Module (MD2)
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Buffer Packets
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Fluorescent Reagent
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Tubing Unions
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Instructions for Use
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Additional Product Information: ​
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Product Brochure ​
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How-To Video
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Instructions for Use
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Frequently Asked Questions
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Application Notes
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Technical Blog​​
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TESTIMONIALS
“Novilytic’s Proteometer is a disruptive breakthrough that finally solves the FDA's requirement to continuously monitor t-mAb proteoforms during fermentation.
The approach improves product safety, reduces COPQ and post release testing, and paves the way for real-time product release, reducing inventory costs.
The solution combines novel sample handing and artificial intelligence with proven analytical technology that is easy to deploy and support, and provides near instantaneous ROI.”
Martin Long, BSc.
Performance Validation, Inc. – President & CEO
(Analytical Sciences Business, Brooks Life Sciences, Thermo, Perkin Elmer)
"As analytical tools have matured for the quality control and characterization of isolated biopharmaceuticals, the application of advanced analytical systems to dynamically contribute to process monitoring and control in complex bioreactors is critical for enhanced process efficiency and product quality.
The Proteometer is expected to play a central role in the development and commercialization of next-level biological manufacturing control strategies. The integration of complementary bioprocess analytical data facilitates decision-making through a powerful link between the manufacturing space and the QC laboratory."